Lista wybranych publikacji
Lista wybranych publikacji
Wybrane publikacje 2017-2021
Rok 2021
Storm Hassell-Hart, Sarah Picaud, Raphael Lengacher, Joshua Csucker, Regis Millet, Gilles Gasser, Roger Alberto, Hannah Maple, Robert Felix, Zbigniew J. Leśnikowski, Helen J. S. Stewart, Timothy J. Chevassut, Simon Morley, Panagis Filippakopoulos, John Spencer,
Probing BRD Inhibition Substituent Effects in Bulky Analogues of (+)-JQ1.
Helvetica Chimica Acta., 2021, 104, e2000214, DOI: 10.1002/hlca.202000214
Damian Kaniowski, Katarzyna
Ebenryter-Olbińska, Katarzyna Kulik,
Justyna Suwara, Wojciech Cypryk, Agata Jakóbik-Kolon, Zbigniew Leśnikowski,
Barbara Nawrot
Composites of
nucleic acids and boron clusters (C2B10H12) as
functional nanoparticles for downregulation of EGFR oncogene in cancer cells
International Journal of Molecular Sciences, 2021, 22, 4863. https://doi.org/10.3390/ijms22094863
David Kodr, Cansu Pinar Yenice, Anna Simonova, Dijana Pavlović Saftić, Radek Pohl, Veronika Sýkorová, Mayreli Ortiz, Luděk Havran, Miroslav Fojta, Zbigniew J. Lesnikowski, Ciara K. O'Sullivan, and Michal Hocek
Carborane- or Metallacarborane-Linked Nucleotides for Redox Labelling. Orthogonal Multipotential Coding of all Four DNA Bases for Electrochemical Analysis and Sequencing
Journal of American Chemical Society, 2021, przyjęte do druku
Rok 2020
Dijana Saftić, Mirosława Studzińska, Edyta Paradowska, Ivo Piantanida, Goran Baranović, Magdalena Białek-Pietras and Zbigniew J. Leśnikowski
Comparative study of the effects of ortho-, meta- and para-carboranes (C2B10H12) on the physicochemical properties, cytotoxicity and antiviral activity of uridine and 2’-deoxyuridine boron cluster conjugate.
Bioorganic Chemistry, 2020, 94, 103466. doi.org/10.1016/j.bioorg.2019.103466
Damian Kaniowski, Katarzyna Ebenryter-Olbinska, Katarzyna Kulik, Slawomir Janczak, Anna Maciaszek, Katarzyna Bednarska-Szczepaniak, Barbara Nawrot and Zbigniew Lesnikowski
Boron Clusters as a Platform for New Materials: Composites of Nucleic Acids and Oligofunctionalized Carboranes (C2B10H12) and their Assembly into Functional Nanoparticles Nanoscale, 2020, 12, 103–114 DOI: 10.1039/C9NR06550D
Damian Kaniowski, Katarzyna Kulik, Katarzyna Ebenryter-Olbińska, Ewelina Wielgus,
Zbigniew Leśnikowski and Barbara Nawrot
Metallacarborane Complex Boosts the Rate of DNA Oligonucleotide Hydrolysis in the Reaction Catalyzed by Snake Venom Phosphodiesterase
Biomolecules 2020, 10, 718; doi:10.3390/biom10050718.
Agnieszka Jabłonska, Anna S. Swierzko, Mirosława Studzinska, Patrycja Suski, Jarosław Kalinka, Zbigniew J. Lesnikowski, Maciej Cedzynski, Edyta Paradowska
Insight into the expression of RIG-I-like receptors in human third trimester placentas following ex vivo cytomegalovirus or vesicular stomatitis virus infection
Molecular Immunology, 2020, 126, 143–152.
Zbigniew J. Leśnikowski
What are the current challenges with the application of boron clusters to drug design?
Expert Opinion on Drug Discovery, 2020, DOI: 10.1080/17460441.2021.1867531
Rok 2019
P. Brennecke, D. Rasina, O. Aubi, …. Z. Lesnikowski and forty other co-authors
EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology
SLAS Discovery, 2019, 1–16.
Daria Różycka, Zbigniew J. Lesnikowski, Agnieszka B. Olejniczak
Synthesis of boron cluster analogs of penicillin and their antibacterial activity
Journal of Organometallic Chemistry, 2019, 881 19e24
Adam Mieczkowski, Aleksandra Kierozalska, Magdalena Białek-Pietras, Tomasz M. Goszczyński, Slawomir Janczak, Agnieszka B. Olejniczak, Mirosława Studzińska, Edyta Paradowska and Zbigniew J. Leśnikowski
Comparative study of inorganic, boron-rich cluster and organic, phenyl adenosine modifications: Synthesis and properties
Future Medicinal Chemistry, 2019,11, 1267-1284. doi: 10.4155/fmc-2018-0517
Carla Sardo, Sławomir Janczak and Zbigniew J. Leśniowski
Unusual resistance of cobalt bis dicarbollide phosphate and phosphorothioate bridged esters towards alkaline hydrolysis: The "metallacarborane effect“
Journal of Organometallic Chemistry, 2019, 896, 70-76.
Masahito Mochizuki, Shinichi Sato, Syifa Asatyas, Zbigniew J. Lesnikowski, Tomohiro Hayashi and Hiroyuki Nakamura
Raman cell imaging with boron cluster molecules conjugated with biomolecules
RSC Advances, 2019, 9, 23973–23978.
Rok 2018
Magdalena Białek-Pietras, Agnieszka B. Olejniczak, Edyta Paradowska, Mirosława Studzińska, Agnieszka Jabłońska and Zbigniew J. Leśnikowski
Synthesis, susceptibility to enzymatic phosphorylation, cytotoxicity and in vitro antiviral activity of lipophilic pyrimidine nucleoside/carborane conjugates
Journal of Organometallic Chemistry, 2018, 865, 166-172. doi.org/10.1016/j.jorganchem.2018.03.026
Anna Adamska-Bartłomiejczyk, Katarzyna Bednarska, Magdalena Białek-Pietras, Zofia M. Kiliańska, Adam Mieczkowski, Agnieszka B. Olejniczak, Edyta Paradowska, Mirosława Studzińska, Zofia Sułowska, Jolanta D. Żołnierczyk and Zbigniew J. Lesnikowski
Boron cluster modifications with antiviral, anticancer and modulation of purinergic receptors activities based on nucleoside structure
In “Boron-Based Compounds: Potential and Emerging Applications in Medicine”, (E-M. Hey-Hawkins, C. Vinas-Teixidor, Eds.,), John Wiley & Sons, Inc., Chapter 1.2, pp 20-34, 2018.
Marian Vincenzi, Katarzyna Bednarska and Zbigniew J. Leśnikowsk
Comparative study of carborane- and phenyl-modified adenosine derivatives as ligands for the A2A and A3 adenosine receptors based on a rigid in silico docking and radioligand replacement assay
Molecules 2018, 23, 1846; doi:10.3390/molecules23081846
Agnieszka B. Olejniczak and Zbigniew J. Lesnikowski
Boron Clusters as Redox Labels for Nucleosides and Nucleic Acids
In “Handbook of Boron Science with Applications in Organometallics, Catalysis, Materials and Medicine”, Vol. 4 Boron in Medicine (Narayan S. Hosmane, Robert Eagling, Eds.,),World Scientific, NJ., Chapter 1, pp 1-13, 2018.
Agnieszka B. Olejniczak, Barbara Nawrot and Zbigniew J. Lesnikowski
DNA Modified with Boron–Metal Cluster Complexes [M(C2B9H11)2]—Synthesis, Properties, and Application
International Journal of Molecular Sciences 2018, 19, 3501; doi:10.3390/ijms19113501.
Dijana Saftić, Biserka Žinić, Ljubica Glavaš-Obrovac, Mirosława Studzińska, Edyta Paradowska, Zbigniew J. Leśnikowski
Synthesis and in vitro evaluation of antiviral and cytostatic properties of novel 8-triazolyl acyclovir derivatives
Nucleosides, Nucleotides and Nucleic Acids, 2018, 37, 397-414. DOI: 10.1080/15257770.2018.1485932
Rok 2017
Mirosława Studzińska, Agnieszka Jabłońska, Małgorzata Wiśniewska-Ligier, Dorota Nowakowska, Zuzanna Gaj, Zbigniew J. Leśnikowski, Teresa Woźniakowska- Gęsicka, Jan Wilczyński, Edyta Paradowska
Association of TLR3 L412F Polymorphism with Cytomegalovirus Infection in Children
PLoS ONE, 12, 2017: e0169420. doi:10.1371/journal.pone.0169420,
M.L. Kowalski, A. Wardzynska, M. Studzinska, M. Pawelczyk, Z.J. Lesnikowski, E. Paradowska
Cytomegalovirus DNA is highly prevalent in the blond of patients with asthma and is associated with age and asthma traits
Allergy, 2017, 72, 2035-2038.
Damian Kaniowski, Katarzyna Ebenryter-Olbinska, Milena Sobczak, Błazej Wojtczak, Sławomir Janczak, Zbigniew J. Lesnikowski, and Barbara Nawrot
High Boron-loaded DNA-Oligomers as Potential Boron Neutron Capture Therapy and Antisense Oligonucleotide Dual-Action Anticancer Agents
Molecules 2017, 22, 1393; doi:10.3390/molecules22091393,
Tomasz M. Goszczyński, Krzysztof Fink, Konrad Kowalski, Zbigniew J. Leśnikowski, Janusz Boratyński
Interactions of Boron Clusters and their Derivatives with Serum Albumin
Scientific Reports, | 7: 9800 | DOI:10.1038/s41598-017-10314-0,
Katarzyna Ebenryter-Olbińska, Damian Kaniowski, Milena Sobczak, Błażej A.Wojtczak, Sławomir Janczak, Ewelina Wielgus, Barbara Nawrot and Zbigniew J. Leśnikowski
Versatile method for the site specific modification of DNA with boron clusters – Anti-EGFR antisense oligonucleotide case
Chemistry - European Journal, 2017, 23, 16535-16546,
Irina Kosenko, Ivan Ananyev, Anna Druzina, Ivan Godovikov, Julia Laskova, Vladimir Bregadze, Miroslawa Studzinska, Edyta Paradowska, Zbigniew J. Lesnikowski, Andrey Semioshkin
Disubstituted cobalt bis(1,2-dicarbollide)(-I) terminal alkynes: Synthesis, reactivity in the Sonogashira reaction and application in the synthesis of cobalt bis(1,2-dicarbollide)(-I) nucleoside conjugates
Journal of Organometallic Chemistry, 2017, 849-850, 142-149. http://dx.doi.org/10.1016/j.jorganchem.2017.02.030.
Jana Balintová, Anna Simonova, Magdalena Białek-Pietras, Agnieszka Olejniczak, Zbigniew J. Lesnikowski, Michal Hocek
Carborane-linked 2'-deoxyuridine 5'-O-triphosphateas building block for polymerase synthesis of carborane-modified DNA.
Bioorganic and Medicinal Chemistry Letters, 2017, 27, 4786-4788.
Ochrona własności intelektualnej:
Pateny:
1. Schinazi R.F., Fulcrand-El Kattan G., Leśnikowski Z.J., Nucleosides and oligonucleotides containing boron clusters, U.S. Patent No. 6,180,766 (30.01.2001).
2. Leśnikowski Z.J., Przepiórkiewicz, M., Paradowska, E., Cieślikowski, T. Oligonucleotide, its use and application for detection of cytomegalovirus (HCMV) Polish Patent Office, Patent Number: P.189683 (14.01.2005).
3. Zbigniew J. Leśnikowski, Agnieszka Olejniczak, Nucleoside derivatives, modified oligonucleotide, method for their synthesis and application thereof, Polish Patent Office, Patent Number: P 359949 (22-06-2010).
4. Zbigniew J. Leśnikowski and Agnieszka Olejniczak, Nucleoside Derivative, Modified Oligonucleotide, Method for Their Synthesis And Applications Thereof, U.S. Patent No. 8,026,348 issued on September 27, 2011.
5. Janusz Boratyński, Tomasz Goszczyñski, Konrad Kowalski, Zbigniew Leśnikowski
Sposób otrzymywania koniugatów białko-klaster boru w fazie stałej
Urzdą Patentowy RP, Nr P. 398 379. (14.12.2015)
6. Janusz Boratyñski, Tomasz Goszczyñski, Konrad Kowalski, Zbigniew Leśnikowski
Sposób otrzymywania koniugatów białko-klaster boru w roztworze, Urząd Patentowy RP, Nr P. 398 380. (21.06.2016)
7. Edyta Paradowska, Mirosława Studzińska, Zbigniew Leśnikowski, Patrycja Suski, Sposób badania aktywności przeciwwirusowej związków względem HCMV, Urząd Patentowy RP, Nr P.394 695 (15.12.2017)
8. Jerzy Radecki, Hanna Radecka, Iwona Grabowska, Agnieszka Sirko, Anna Góra-Sochacka, Zbigniew Leśnikowski, Agnieszka Olejniczak, Bioczujnik elektrochemiczny oraz zastosowanie bioczujnika, Urząd Patentowy RP, Nr P.222314 (29.07.2016).
9. Agnieszka B. Olejniczak, Zbigniew J. Leśnikowski, Daria Różycka, Pochodne kwasu 6-aminopenicylanowego (6-APA), związki pośrednie oraz zastosowanie medyczne pochodnych kwasu 6-aminopenicylanowego. Urząd Patentowy RP, patent Nr. 234565, 30.04.2020
